Principal Scientist - Stem Cell Biology

About Us #

We are on a mission to reshape regenerative medicine. Current reprogramming methods are slow, inefficient, and often unpredictable - we believe bioelectric modulation holds the key to unlocking faster, more efficient reprogramming.

Traditional methods use a ‘bottom up’ approach that has low efficiency and variable quality. The bioelectric method would be a ’top down’ approach that acts on the physiology of the cell to have a more dramatic and immediate effect. Aion Biosciences aims to develop the bioelectric method, then combine these approaches to ‘meet in the middle’, with two initial goals:

1. Increase reprogramming efficiency by an order of magnitude
2. Cut the time of current reprogramming methods by half

These goals are ambitious; however, they are an essential proof-of-concept for technologies Aion Biosciences will develop and introduce into the field of regenerative medicine in the coming years.

Key Responsibilities #

• Develop and optimize protocols integrating bioelectric modulation with a range of reprogramming methodologies.
• Analyze complex datasets to identify optimal bioelectric parameters for reprogramming.
• Work closely with our business team to ensure that our scientific advancements align with and drive our strategic goals.
• Adapt quickly to changing priorities and drive projects with minimal supervision.

Requirements #

• Ph.D. in Bioengineering, Stem Cell Biology, or a related field.
• 3+ years of post-PhD experience in stem cell biology or a related field.
• Strong foundation in cellular biology and bioengineering; experience with bioelectricity/ion channels is a plus, but not required.
• Strong background in iPSC generation and characterization.
• Background in bioinformatics and data analysis, with proficiency in Python and/or R is a plus, but not required.
• Proven track record of designing experiments resulting in either high-impact publications or commercial endpoints.
• Hands-on experience with CRISPR-Cas9, optogenetics, single-cell RNA sequencing, and patch-clamp electrophysiology is highly desirable.
• Basic understanding of IP strategy and regulatory pathways in biotech are preferred.

Essential Qualities #

• Entrepreneurial mindset with a high tolerance for ambiguity and risk.
• Exceptional problem-solving skills and ability to work with limited resources.
• Strong communication skills, able to convey complex ideas to diverse audiences.
• Flexibility to wear multiple hats and adapt quickly to changing priorities.
• Passion for translating cutting-edge science into real-world applications.

What We Offer #

• Competitive salary, based on experience.
• Substantial equity stake
• Opportunity to shape a potentially industry-defining company from its inception.
• Autonomy to drive critical scientific and business decisions.
• A collaborative environment where your ideas will be heard and valued.
• Opportunity to work on technology with the potential to transform regenerative medicine.

Our Setup #

We currently operate out of a small but functional lab space in St. Louis. As one of our first scientific hires, you’ll have input on future equipment acquisitions and lab expansion as we grow.

To Apply #

Please send your CV and a brief statement on why you’re excited about joining Aion Biosciences to hiring@aion.bio. We review applications on a rolling basis, with an expected start date within 1-2 months after the offer.

At Aion Biosciences, we’re building a company that could reshape regenerative medicine. If you’re ready for the challenge of your career and want to make a real impact, we want to hear from you.

Aion Biosciences is an equal opportunity employer. We believe varied perspectives fuel innovation and are committed to creating an environment where everyone can thrive.